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General

Fracture Risk Is Increased In Epilepsy

Di: Amelia

Studies suggest that persons with epilepsy treated with antiepileptic drugs (AEDs) may be at an increased risk for bone disease including changes in bone turnover,

Epilepsy, osteoporosis and fracture risk

(PDF) Epilepsy, osteoporosis and fracture risk – a meta-analysis ...

A person with post-traumatic epilepsy (PTE) is someone with risk for recurrent seizures as a result of a brain injury. About 1 in 50 people who have traumatic brain injuries will go on to develop People with epilepsy face many challenges beyond seizures themselves, including several potential comorbidities that can affect their long-term health. One significant There is a growing volume of literature suggesting that chronic use of AED in patients with epilepsy significantly reduces bone mineral density (BMD) with an increased

Epileptic patients on phenytoin therapy that were 18–55 years old exhibited higher associated risk of osteoporosis and osteoporotic-fragility fractures of various regions. Patients

Background Epilepsy is a common chronic neurological disorder, usually requiring long-term treatment with anti-epileptic drugs (AED). Many studies have reported that AED Falls and fractures in patients with epilepsy Is there an increased risk? If so, why? Alison M. Pack, MD, MPH Authors Info & Affiliations July 10, 2012 issue 79 (2) 119-120 A search of PubMed was conducted using the key words epilepsy, fracture, and bone mineral. A weighted estimate of relative risk of fractures and changes in BMD (Z-score)

Menopausal women with epilepsy present several unique management challenges. They have an elevated risk for osteoporotic fracture because of the adverse effects Falls and fractures in patients with epilepsy: is particularly is there an increased risk? If so, why? People with epilepsy face many challenges beyond seizures themselves, including several potential comorbidities that can affect their long-term health. One significant

The increased risk of fractures during the first years could partly be explained by the observation that the risk of seizures in epilepsy tends to decline over time (15).

The expected increases in relative risk of any fracture from BMD Z -scores were 1.2–1.3, and significantly lower than observed (2 P < 0.05). The deficit in BMD in patients with epilepsy is This study aimed to investigate the prevalence of fractures and non-fracture injuries, including associated risk factors, in children with epilepsy prescribed antiseizure medications

1. Introduction The occurrence of skeletal fractures in people with epilepsy is increased compared with the general popula-tion, although the risk varies with a number of factors [1–8]. The From the changes in BMD, expected increase in relative fracture risk was calculated. The From A total of 11 studies on fracture risk and 12 studies on BMD were retrieved. Patients with epilepsy have a higher risk of skeletal injuries, and some of these fractures occur in the spine during a seizure. Seizure-induced spinal fractures (SISF) are unusual injuries that

Background Epilepsy-related injuries and accidents (ERIA) are a frequent cause of hospitalisation and represent a relevant burden for patients with epilepsy. In particular, Conclusions: The overall risk of fractures was nearly twice as high among patients with epilepsy mineral density BMD with compared with the general population. The relative fracture risk was highest for Abstract Background Osteoporosis is a bone disorder defined by a decrease in bone mineral density (BMD) which can lead to an increased risk of fractures. Patients with epilepsy are more

Abstract In recent years there has been increasing evidence suggesting that epilepsy and its treatment can have adverse effects on bone mineralization

Conclusions: The overall risk of fractures was nearly twice as high among patients with epilepsy to six times greater than compared with the general population. The relative fracture risk was highest for

The increased risk of fractures during the first years could partly be explained by the observation that the risk of seizures in epilepsy tends to decline over time 15. Liver enzyme inducing antiepileptic drugs (LEI AEDs) have adverse effects on bone metabolism but it than observed 2 P 1 is unclear whether this translates into increased fracture risk. This population Adults taking antiepileptic drugs (AEDs) have an augmented risk for osteopenia and osteoporosis because of abnormalities of bone metabolism associated with AEDs. The increased fracture

The risk for skeletal fractures in patients with epilepsy is two to six times greater than in the general population. Fractures may be caused by seizures themselves or by falls, increased risk Results: The study population comprised 1,018 cases and 1,842 matched controls. The risk of fractures increased with cumulative duration of exposure (p for trend < 0.001), with

To evaluate whether exposure to CYP3A4 inducing antiepileptics increases fracture risk compared to CYP3A4 non-inducing antiepileptics.We performed a retrospective cohort study of Women with epilepsy present with unique challenges due to cyclical fluctuation of hormone levels from the onset of menstruation to menopause. The menopausal period is particularly Fracture risk is increased in epilepsy Peter Vestergaard, S. Tigaran, Lars Rejnmark, C. Tigaran, M. Dam, Leif Mosekilde

In postmenopausal women, raloxifene increases bone mass and reduces the risk of vertebral fracture by 40% to 50% (48, 49). Side effects include an increased risk of deep venous