Published Online In The Lancet On February 27, 2017

Di: Amelia

Explore original research, reviews, and topical comments about diabetes, endocrinology, and metabolism from The Lancet Diabetes & Endocrinology The Commission identified 66 reports published by UN agencies and independent groups between 2007 and Lancet Commission on 2017, related to obesity, undernutrition, climate change, or physical activity. Of the most recent reports with high-authoritative impact (n=11), a subset of reports (n=5) presented 255 specific recommendations for governments (appendix p 13).

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We searched Cochrane Library, MEDLINE, and Embase for manuscripts published between Jan 1, 2000, and Dec 31, 2016, using the terms “type 2 diabetes” and “type 2 diabetes mellitus”. We largely selected articles published in the past 5 years but did not exclude commonly referenced and highly regarded, older articles. Estimated geographical and temporal distribution of lung-cancer incidence varied across the four main subtypes worldwide. Our study highlights the need for future studies that identify possible causal factors that contribute RSV contributes substantially to morbidity and mortality burden globally in children aged 0–60 months, especially during the first 6 months of life and in LMICs. We highlight the striking overall mortality burden of RSV disease worldwide, with one in every 50 deaths in children aged 0–60 months and one in every 28 deaths in children aged 28 days to 6 months attributable to RSV.

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Preoperative GLP-1 RA therapy may support clinically meaningful weight loss without a clear signal of increased perioperative risk, offering a potentially scalable strategy for surgical optimisation. However, the certainty of current evidence is very low, with most studies observational in design and at risk of bias. Amid rising global obesity rates and mounting Methods We did a systematic review and network meta-analysis. We searched Cochrane Central Register of Controlled Trials, CINAHL, Embase, LILACS database, MEDLINE, MEDLINE In-Process, PsycINFO, the websites of regulatory agencies, and international registers for published and unpublished, double-blind, randomised controlled trials from their inception to Jan 8, 2016.

We reconvened the 2017 Lancet Commission on dementia prevention, intervention, and care 2 to identify the evidence for advances likely to have the greatest impact since our 2017 paper and build on its work. Our interdisciplinary, international group of experts presented, debated, and agreed on the best available evidence. Cryptococcosis is a major worldwide disseminated invasive fungal infection. Cryptococcosis, particularly in its most lethal manifestation of cryptococcal meningitis, accounts for substantial mortality and morbidity. The breadth of the clinical cryptococcosis syndromes, the different patient types at-risk and affected, and the vastly disparate resource settings where The mortality of critically ill patients with SARS-CoV-2 pneumonia is considerable. The survival time of the non-survivors is likely to be within 1–2 weeks after ICU admission. Older patients (>65 years) with comorbidities and ARDS are at increased risk of death. The severity of SARS-CoV-2 pneumonia poses great strain on critical care resources in hospitals, especially if

Exenatide had positive effects on practically defined off-medication motor scores in Parkinson’s disease, which were sustained beyond the period of exposure. Whether exenatide affects the underlying disease pathophysiology or simply induces long-lasting symptomatic effects is uncertain. Exenatide represents a major new avenue for investigation in Parkinson’s

Higher recreational and non-recreational physical activity was associated with a lower risk of mortality and CVD events in individuals from low-income, middle-income, and high-income countries. Increasing physical activity is a simple, widely applicable, low cost global strategy with country specific data that could reduce deaths and CVD in middle age. Current BMI-based measures of obesity can both underestimate and overestimate adiposity and provide inadequate information about health at the individual level, which undermines medically-sound approaches to health

Methods We did a series of systematic reviews and meta-analyses of prospective studies published from database inception to April 30, 2017, and randomised controlled trials published from database inception to Feb 28, 2018, which reported on indicators of carbohydrate quality and non-communicable disease incidence, mortality, and

Global Burden of Disease 2019

Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual

The Lancet, 04 January 2025, Volume 405, Issue 10472, Pages 1-96
Global Burden of Disease 2019
Dementia prevention, intervention, and care: 2020 report of the
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Added value of this study To our knowledge, the S0777 study is the first to show that an all novel triple drug combination (bortezomib, lenalidomide, and dexamethasone) used in the absence of autologous stem-cell transplant is superior to a double drug novel combination (lenalidomide and dexamethasone) in terms of progression-free survival and overall survival in patients with Summary Background Mental disorders are among the leading causes of non-fatal disease burden in India, but a systematic understanding of their prevalence, disease burden, and risk factors is not readily available for each state of India. In this report, we describe the prevalence and disease burden of each mental disorder for the states of India, from 1990 to 2017. The Global Burden of Disease Study provides a roadmap to where need is greatest, with country-specific data on risk factors and chronic disease burden. Access all GBD papers published by The Lancet Group online in the Lancet Global Burden of Disease Resource Centre, or explore key messages in the infographics below.

The 2024 update of the Lancet Commission on dementia provides new hopeful evidence about dementia prevention, intervention, and care. As people live longer, the number of people who live with dementia continues to Summary Background Management strategies and clinical outcomes vary substantially in patients newly diagnosed with Crohn’s disease. We evaluated the use of a putative prognostic biomarker to guide therapy by assessing outcomes in patients randomised to either top-down (ie, early combined immunosuppression with infliximab and immuno-modulator) or accelerated step-up

In this study of adult patients admitted to hospital for severe COVID-19, remdesivir was not associated with statistically significant clinical benefits. However, the numerical reduction in time to clinical improvement in those treated earlier requires confirmation in larger studies. Jan 04, 2025 Volume 405 Number 10472 p1-96 Current Issue Online First Download full issue Register for eTOC alerts

Mental ill health, which has been the leading health and social issue impacting the lives and futures of young people for decades, has entered a dangerous phase. Accumulating research evidence indicates that in many countries, the mental

This novel extension of the GBD Study shows the untapped potential for personal health-care access and quality improvement signal of across the development spectrum. Amid substantive advances in personal health care at the national level,

The Lancet, 04 January 2025, Volume 405, Issue 10472, Pages 1-96

There is more than a 50% probability that by 2030, national female life expectancy will break the 90 year barrier, a level that was deemed unattainable by some at the turn of the 21st century. Our projections show continued increases in longevity, and the need for careful planning for health and social services and pensions. No studies, however, provided comprehensive estimates covering all locations and a broad range of pathogen–drug combinations until the global burden of AMR in 2019 study was published. The study estimated that Online First Below are the latest The Lancet articles published online ahead of print Many research papers will have been peer-reviewed and published via our fast-track process within 4 weeks of submission Current Issue Online First

The Lancet Countdown is an international research collaboration that independently monitors the evolving impacts of climate change on health, and the emerging health opportunities of climate action. In its eighth iteration, this 2023 report draws on the expertise novel extension of 114 scientists and health practitioners from 52 research institutions and UN Socioeconomic circumstances, in addition to the 25 × 25 factors, should be targeted by local and global health strategies and health risk surveillance to reduce mortality.

In 2017, WHO published a priority list for developing new and effective antibiotic treatments. The list was intended to inform research and development priorities related agreed on the to new antibiotics and put the most emphasis on pathogens with multidrug resistance that cause severe and often deadly infections in health-care and nursing home

In 2017, systematic reviews and meta-analyses of observational studies suggested a benefit of oral anticoagulants (mostly vitamin K antagonists) for the prevention of ischaemic stroke in survivors of intracerebral haemorrhage, 7,8 and one large national register-based study showed a 45% reduction in mortality in patients receiving The December, 2019 coronavirus disease outbreak has seen many countries ask people who have potentially come into contact with the infection to isolate themselves at home or in a dedicated quarantine facility. Decisions on how to apply quarantine should be based on the best available evidence. We did a Review of the psychological impact of quarantine using three

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