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The Human Plasma Proteome | Human Plasma PeptideAtlas

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Here the authors study the relationship between 1000 plasma proteins and body mass index (BMI), highlighting widespread proteome changes and causal relationships between BMI and specific proteins.

6月18日，英国生物样本库联合数十家药厂发布题目为「 Genetic regulation of the human plasma proteome in 54,306 UK Biobank participants」的论文，首次发布基于Olink Explore平台的开创性蛋白组学研究进展。文中首次披露针对54,306参与者的蛋白组学和基因测序的数据进行pQTL（Protein Quantiative Trait Loci）Mapping分析，通过对 Fig. 3 Reference intervals for 70 protein analytes in plasma. Abundance is plotted on a log scale spanning 12 orders of magnitude. Where only an upper limit is quoted, the lower end of the interval line shows an arrowhead. Plasma proteomics holds immense potential for clinical research and biomarker discovery, serving as a non-invasive „liquid biopsy“ for tissue sampling. Mass spectrometry (MS)-based proteomics, thanks to improvement in speed and robustness, emerges as an ideal technology for exploring the plasma proteome for its unbiased and highly specific protein

Human Plasma PeptideAtlas

Human proteome distribution atlas for tissue-specific plasma proteome ...

Plasma proteomics is a precious tool in human disease research but requires extensive sample preparation in order to perform in-depth analysis and biomarker discovery using traditional data-dependent acquisition (DDA). Here, we highlight the efficacy of combining moderate plasma prefractionation and data-independent acquisition (DIA) to significantly

Large-scale, unbiased proteomics studies of biological samples like plasma are constrained by the complexity of the proteome. Herein, the authors develop a highly parallel protein quantitation The study provides an updated characterization of the genetic architecture of the plasma proteome, contextualized with projected pQTL discovery rates as sample sizes and proteomic assay coverages increase over time. This open-access atlas of the human plasma proteome nevertheless provides new insights into the biological mechanisms of different diseases, supporting researchers in understanding and assessing disease biomarkers and finding potential therapeutic targets.

Human blood plasma provides a highly accessible window to the proteome of any individual in health and disease. Since its inception in 2002, the Human Proteome Organization’s Human Plasma Proteome Project (HPPP) has been promoting advances in the study and understanding of the full protein complement of human plasma and on determining the The proteome is fundamental to human biology and health but little is known about ancestral diversity of its genetic determinants. In GWAS of plasma levels of 2,923 proteins in 3,974 Chinese adults, we identified pQTLs for 1,784 proteins, including 1,312 cis -pQTLs for 1,264 proteins. Fine-mapping identified 3,475 credible sets for independent pQTLs, 36% of which The human plasma proteome is underexplored, despite its potential value for monitoring health and disease. Herein, using a recently developed aptamer-based platform, we profiled 7,288 proteins in 528 plasma samples from 91 normal pregnancies (Gene

Genomic atlas of the human plasma proteome Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control inter-individual variation in plasma protein levels are not well understood. The proteome is fundamental to human biology and disease but little is known about ancestral diversity of its genetic determinants. In GWAS of plasma levels of 1,451 proteins the heritable component of in 3,974 Chinese adults, we identified pQTLs for 1,082 proteins, including 743 with at least one cis This study aimed to explore how gene-environment interactions (GEIs) affect protein levels in the human body, specifically within the plasma proteome. The focus was on identifying variance quantitative trait loci (vQTLs) that signal these interactions, and understanding how genetic and environmental factors together influence protein

The human blood plasma harbors treasure, which, like most treasures, is not easily attained, and finding it requires ingenuity, endurance and possibly a grain of luck. The blood most if not all human plasma is the largest (most proteins) and deepest (widest dynamic range) of the human proteomes. In order to ‘triumph over’ it, it is necessary to overcome an enormous protein

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THE GRAND PROJECT a function for every proteinContact Us Methods: This study employed proteome-wide Mendelian randomization (MR) and colocalization analyses. We collected data on 1394 plasma proteins from a range of protein quantitative trait loci (pQTL) study involving 4907 individuals. Genetic associations with LUAD were derived from the Transdisciplinary Research in Cancer of the Lung (TRICL) study, including 11,245

Undulating changes in human plasma proteome across lifespan are linked ...

Three papers in Nature report on the largest open-access plasma proteomics dataset to date, a valuable resource for understanding human disease and the identification of drug targets. Hier sollte eine Beschreibung angezeigt werden, diese Seite lässt dies jedoch nicht zu.

The Human Proteome Organization (HUPO) is an international scientific organization representing and promoting proteomics through international cooperation and collaborations by fostering the development of new technologies, techniques and training.

The plasma proteome is maintained by the influx and efflux of proteins from surrounding organs and cells. To quantify the extent to which different organs and cells impact the plasma proteome in healthy and diseased conditions, we developed a mass-spectrometry-based proteomics strategy to infer the tissue origin of proteins detected in human plasma. We first Large-scale proteomics studies can refine our understanding of health and disease and enable precision medicine. Here, we provide a detailed atlas of 2,920 plasma proteins linking to diseases (406 prevalent and 660 incident) and 986 health-related traits in 53,026 individuals (median follow-up: 14.8

We have merged four different views of the human plasma proteome, based on different methodologies, into a single nonredundant list of 1175 distinct gene products. The methodologies used were 1) literature search for proteins reported to occur in plasma or serum; 2) multidimensional chromatography o

Mendelian randomization can be used to mimic the effects of protein-targeting drugs in a population of individuals. Here, the authors have identified potential causal proteins for stroke in a two The UK Biobank Pharma Proteomics Project (UKB-PPP) is a collaboration between mechanisms of the UK Biobank (UKB) and thirteen biopharmaceutical companies characterising the plasma proteomic profiles of 54,306 UKB participants. Here, we describe results from the first phase of UKB-PPP, including protein quantitative trait loci (pQTL) mapping of 1,463 proteins

Furthermore, we functionally interpret a 1,000-protein, quantitative plasma proteome obtained by simple peptide pre-fractionation. Plasma proteome profiling delivers an informative portrait of a person’s health state, and we envision its large-scale use in biomedicine. Home Human Proteome Project (HPP) B/D-HPP Human Plasma Proteome Project (HPPP) Terms Reso urces News Human blood plasma provides a highly accessible window to the proteome of any individual in health and disease. Since its inception in 2002, the Human Proteome Organization’s Human Plasma Proteome Project (HPPP) has been promoting advances in the

Human Plasma Proteome Project Data Central at PeptideAtlas Welcome to the HUPO/HPPP Data Central, hosted at PeptideAtlas.

We performed TWAS for thousands of plasma proteins, comparing same-gene, cis, and trans effects across tissues. We show the heritable component of gene expression more strongly correlates with protein levels than with total observed expression and is therefore more useful in uncovering the functions of SNPs associated with complex traits. Blood plasma is an exceptional proteome in many respects. It is the most complex human-derived proteome, containing other tissue proteomes as subsets. It is collected in huge amounts (millions of liters) for preparation of protein therapeu-tic products. It is the most difficult protein-containing sample to characterize on account of the large proportion of albumin (55%), the wide dynamic The human plasma proteome holds the promise of a revolution in disease diagnosis and therapeutic monitoring provided that major challenges in proteomics and related disciplines can be addressed.

As a contribution to the Human Proteome Organization (HUPO) Human Plasma Proteome Project (HPPP), the scientists present the Human Plasma PeptideAtlas build 2021-07 that comprises 4395 canonical and 1482 additional nonredundant human proteins detected in 240 MS-based experiments. The authors systematically study biological influences on the human plasma proteome in a large cohort, thereby revealing causal associations between plasma proteins and modifiable risk factors for protein–disease associations.

The Human Proteome Organization (HUPO) in 2003 launched an effort to combine results from the many labs around the world who were working on the human plasma proteome. This effort, the Human Plasma Proteome Project (HPPP), continues today and the PeptideAtlas is an integral part of that effort. The human plasma proteome is likely to contain most, if not all, human proteins, as well as proteins derived from some viruses, bacteria, and fungi. Many of the human proteins, introduced by low-level tissue leakage, ought to be present at very low concentrations ( pg/ml), while others, such as al-bumin, are present in very large amounts ( mg/ml).