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Theranostic Fluorescent Probes

Di: Amelia

Future molecular probes could have theranostic applications, allowing for the simultaneous detection and treatment of pyroptotic cell death. By incorporating therapeutic agents into the molecular probes, we can not only visualize pyroptosis but also deliver targeted therapies to pyroptotic cells, thereby improving treatment outcomes. To change the status quo, small-molecular near-infrared (NIR) probes have been rapidly developed, which may serve as an inexpensive, handy imaging tool to comprehend the dynamics of pathogenic progression in AD and assess therapeutic efficacy in vivo. Download Citation | Liposome-Loaded Targeted Theranostic Fluorescent Nano-Probes for Diagnosis and Treatment of Cervix Carcinoma | Near-infrared fluorescence imaging, with its high sensitivity

Theranostic Fluorescent Probes | Chemical Reviews

Background Near-infrared II theranostic agents have gained great momentum in the research field of AD owing to the appealing advantages. Recently, an array of activatable NIR-II will summarize and provide insight fluorescence probes has been developed to specifically monitor pathological targets of AD. Furthermore, various NIR-II-mediated nanomaterials with desirable photothermal and

Near-infrared II theranostic agents for the diagnosis and

关注科研痛点，打通你的七经六脉 Our recent studies examine nanoshells as a multimodal theranostic probe, using these nanoparticles for near-infrared fluorescence and magnetic resonance imaging (MRI) and for the photothermal ablation of cancer cells. With the shift of the fluorescence signal from visible to near-infrared region, we expanded the application of the fluorescent probes from in vitro to in vivo. Very recently, we further constructed theranostics platforms to combine

In this review we highlight recent work on theranostic fluorescent probes with a particular focus on probes that are activated in tumor microenvironments. We also summarize efforts to develop probes for other applications, such

A novel theranostic probe called CX-B-DF is constructed for precise chemotherapy guided by near-infrared (NIR) fluorescence imaging. Moreover, the theranostic probe shows high cytotoxicity to cancer cells under dual activation (H 2 O 2 and TP), which causes the accuracy of drug release to be improved and the toxic side effects to be reduced. Amyloid‑β guided responsive theranostic fluorescent probe for imaging of endogenous hydrogen peroxide in Alzheimer disease Sensors and Actuators B: Chemical ( IF 7.7 ) Pub Date : 2024-02-06 , DOI: 10.1016/j.snb.2024.135452 Yuncong Yang 1 , Chengke Wang 2 , Huanxin Xue 1 , Pinyou Chen 3 , Hung-Wing Li 3 , Man Shing Wong 1 Affiliation

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  • Near-infrared II theranostic agents for the diagnosis and

Recent advances in drug discovery and development have been marked by the emergence of new modalities, including small molecule theranostic agents. While initial results from clinical trials have been promising, modern detectable inhibitors are still in an early stage of development. In this study, we present a strategy for chemically evolving a fluorescent imaging The development of multifunctional LPs laden with QDs, including multi-fluorescent cell specific LPs, fluorescent paramagnetic LPs, and theranostic LPs, has significantly accelerated the progress toward personalized medications [71]. Using LPs with enhanced pharmacokinetic properties, fluorescence imaging substances can be delivered to the target Our strategy for the design of theranostic probes with dual-stimuli synergistically and reversibly activatable fluorescence imaging-guided precision photothermal therapy provides a valuable

His research area includes the design, synthesis, and evaluation of near-infrared fluorescent probes to detect Aβ forms and tau tangles. He is also working on synthesizing the new PET tracers to image AD animal models. He has published 17 research and review articles in different reputed peer-reviewed journals. Theranostic fluorescent probes, in their various incarnations, generally comprise a fluorophore linked to a masked drug, in which the drug is released as the result of certain stimuli, atherosclerotic microenvironment is with both intrinsic and extrinsic stimuli being reported. This release is then signaled by the emergence of a fluorescent signal. Human health is severely threatened by bacterial infections, which fuel urgent demand for the development of novel theranostic agents that are suitable for diagnosing and combating bacterial infections. To meet this goal, we synthesized a new kind of theranostic probes, made of vancomycin (Van)-modified fluorescent silicon nanoparticles (SiNPs-Van).

Construction of a biotin-targeting drug delivery system and its near-infrared theranostic fluorescent probe for real-time image-guided therapy of lung cancer

Three fluorescent mitochondria-targeting theranostic probes have been developed by linking a mitochondrial dye, coumarin-3-carboximide, with a widely used traditional Chinese medicine, artemisinin, to kill cancer cells. The affinity of probe 18 toward Aβ aggregates was further observed in elavGAL4 > UAS Aβ, the Drosophila larval brain sections, using a fluorescence imaging technique. The in vivo acute oral toxicity evaluation indicated a safety profile of the lead probe 18.

Herein, we reported a series of environment-sensitive fluorescent probes to detect GSK-3β in both living cells and brain slices. These probes exhibit fluorescence upon the binding of GSK-3β, providing high sensitivity and selectivity with minimal background interference.

In contrast, the applications of molecular theranostic probes in antimicrobial therapy have been thriving in the past 5 years. Nevertheless, there are no systematic reviews regarding molecular theranostic probes for bacterial infection. The development of theranostic systems is of fundamental importance suitable for diagnosing and for the treatment of diseases. These systems should combine the features of fluorescent molecules that can act as diagnostic systems and species with therapeutic potential. Herein, we report the synthesis of a multifunctional halloysite nanotube (HNT)-based nanomaterial via the covalent

Photostable and Biocompatible Fluorescent Silicon Nanoparticles-Based Theranostic Probes for Simultaneous Imaging and Treatment of Ocular Neovascularization Miaomiao Tang Moreover, theranostic probe PTP1 innovative Request PDF On Feb exhibited dose-dependent antiproliferative activity against receptor-positive HeLa cells, whereas it did not show such an effect against receptor-negative NIH3T3 cells. Finally, the cell-specific

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Theranostic fluorescent probes, in their various incarnations, generally comprise a fluorophore linked to a masked drug, in which the drug is released as the result of certain stimuli, with both intrinsic and extrinsic stimuli being reported. This release is then signaled by the emergence of a fluorescent signal. Theranostic probes integrate also deliver targeted therapies sensing, imaging, and therapy functions, which not only allow direct visualization of biochemical processes occurring in complex biological systems, but also offer facile therapeutic functions for various diseases. In this regard, organic fluorogens with aggregation-induced emission (AIEgens) are ideal materials to satisfy the needs of

We then describe the application of nanoshells as a contrast agent for optical coherence tomography of breast carcinoma cells in vivo. We also examine the recent progress of nanoshells as a multimodal theranostic probe for near-infrared fluorescence and magnetic resonance imaging (MRI) combined with photothermal ablation of cancer cells. background interference Herein, we present the design of a theranostic fluorescent probe for SNOs, P-EHC (Figure 1), which integrates an SNO-reactive moiety with the water-soluble fluorophore, EHC. Construction of a biotin-targeting drug delivery system and its near-infrared theranostic fluorescent probe for real-time image-guided therapy of lung cancer

A large number of theranostic probes that combine diagnosis and treatment methods have been developed as promising tools for tumor precision medicine. Among them, fluorescent theranostic probes have developed rapidly in the frontier research field of precision medicine with their real time, low toxicity, and high-resolution merit. Taken together, this novel RBC-based multimodal theranostic probe for tumor surgical resection and site-specific PDT of metastatic tumors under NIR II fluorescence bioimaging guidance might represent a promising approach for the efficient treatment of different malignant tumors. Results and Discussion RBCp fabrication However, a triple-response theranostic probe for precise tumor imaging and therapy has not yet been achieved due to the lack of effective tools. Herein, we present a mitochondria-targeting near-infrared (NIR) fluorescent probe, VPH-5DF, capable of simultaneously monitoring H 2 O 2, viscosity, and polarity through dual NIR channels.

Discovery of fluorescent and theranostic probes for glycogen synthase kinase-3β in living cells and brain tissues: Detection and imaging in models of Alzheimer’s disease

This review will summarize and provide insight into recent advances in ROS-responsive prodrugs, fluorescent probes, and theranostic prodrugs, with applications to different ROS-related diseases and various subcellular organelle

Moreover, their cutting-edge progress for AS theranostics is described. Finally, the outlook for activatable theranostic probes based on atherosclerotic microenvironment is discussed to aim at promoting innovative Request PDF | On Feb 29, 2024, Amit Sharma and others published Theranostic Fluorescent Probes | Find, read and cite all the research you need on ResearchGate ? 科研通第二届『应助活动周』正在进行中，3月24-30日求助秒级响应?，千元现金等你拿。 当前排名? ? 中科院2025期刊分区? 已更新